ACHE, His-Tag Recombinant

Catalog #

11004

$390 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human ACHE (acetylcholinesterase), encompassing amino acids 32-614(end). This construct contains a C-terminal His-tag (10xHis). The recombinant protein was affinity purified.

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Synonyms

Acetylcholine receptor subunit epsilon, CHRNE, ACHRE, Acetylcholinesterase

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

ACHE inhibition curve using a colorimetric assay (#82281). Representative data only; data may vary by lot.

Product Info

Storage and Usage

Citations

Species

Human

Construct

ACHE (32-614(end)-His)

Host Species/Expression System

HEK293

Purity

≥90%

Format

Aqueous buffer solution

Formulation

8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

66 kDa

Amino Acids

32-614(end)

Genbank #

NM_000665

UniProt #

P22303

Tag(s)

C-terminal His Tag

Background

Acetylcholinesterase (ACHE) is an enzyme that breaks down neurotransmitter acetylcholine (ACh) into acetic acid and choline. The enzyme is expressed as several isoforms differening in their N-terminal and C-terminal domains, and is found primarily in the synaptic gaps of the central and peripheral nervous system, in the muscle, and in the erythrocyte membrane. Its main role is to stop neuronal transmission and signaling between synapses. ACHE inhibitors are used to treat Alzheimer's diseas as they compensate for the death of cholinergic neurons and restore synaptic levels of ACh.

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Datasheets/Protocols

11004 Lot 220531

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ACHE, His-Tag Recombinant

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