ULK3, His-tag Recombinant

Catalog #

40295

$475 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human ULK3, full length, with N-terminal His-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

DKFZP434C131, ULK-3

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥95%

Format

Aqueous buffer solution

Formulation

50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.

51 kDa

Amino Acids

full length

Genbank #

BC157884

UniProt #

Q6PHR2

Tag(s)

N-terminal His-tag

Background

ULK3 or unc-51-like kinase 3 is a member of the serine/threonine kinase family that is involved in the SHH signaling pathway as a positive regulator of GLI proteins (1). ULK3 enhances endogenous and over-expressed GLI transcriptional activity in cultured cells and alters its subcellular localization. Furthermore, ULK3 phosphorylates GLI proteins in vitro. ULK3 is widely expressed and its expression is higher in a number of tissues where SHH signaling is known to be active, again suggesting that ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins.

References

Maloverjan, A. et al: Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. Exp Cell Res. 2010 Feb 15;316(4):627-37.

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ULK3, His-tag Recombinant

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