RIPK1, GST-Tag (Mouse) Recombinant
Catalog #
100340
$375
*
●
●
Purchase
Description
Recombinant mouse RIPK1 (receptor (TNFRSF)-interacting serine-threonine kinase 1), encompassing amino acids 1-327 containing the protein kinase domain. This construct contains an N-terminal GST-tag. The recombinant protein was affinity purified.
●
Synonyms
Cell death protein RIP, Rinp, Receptor-interacting protein 1, Rip1, RIP-1, D330015H01Rik
●
Product Data Gallery
4-20% SDS-Page Coomassie Staining
RIPK1 (Mouse) Activity
Product Info
Storage and Usage
Citations
Species
Mouse
Construct
RIPK1 (GST-1-327) (Mouse)
Host Species/Expression System
Sf9 insect cells
Purity
≥90%
Supplied As
Aqueous buffer solution.
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 3 mM DTT
MW
64 kDa
Amino Acids
1-327
Genbank #
NM_009068
UniProt #
Q60855
Background
RIPK1 or Receptor Interacting Protein Kinase 1 is a serine/threonine kinase that was originally identified as interacting with the cytoplasmic domain of FAS. RIPK1 has been deemed as an important element in the signal transduction machinery that mediates programmed cell death. RIPK1 has been shown to interact with TRADD, TRAF1 TRAF2 and TRAF3 and TRADD can act as an adaptor protein to recruit RIPK1 to the TNFR1 complex in a TNF-dependent process (1). TNFα is capable of activating the noncanonical NF-κB pathway, but this activation of this pathway is negatively regulated by RIPK1 (2).
References
1. Hsu, H. et al., Immunity 4: 387-396, 1996.
2. Kim, J Y. et al., J Cell Sci. 2011 Feb 15;124(Pt 4):647-56.
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.