PDGFRa, GST-tag Recombinant
Catalog #
40261
$410
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Description
Recombinant human PDGFRα (550-end), GenBank accession number NM_006206, with an N-terminal GST-tag, expressed by baculovirus in Sf9 insect cells.
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Synonyms
CD140A, PDGFR2, MGC74795, Rhe-PDGFRA
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Product Data Gallery
10% SDS-PAGE Coomassie Staining
Specific Activity
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
95 kDa
Amino Acids
550–end
Genbank #
NM_006206
UniProt #
P16234
Background
PDGFRα (platelet-derived growth factor receptor α) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes (1). PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase (2).
References
1. Floege, J. et al. J Am Soc Nephrol. 1998 Feb,9(2):211-23.
2. Kumagai, S. et al. Tohoku J Exp Med. 2001 Sep,195(1):21-33.
2. Kumagai, S. et al. Tohoku J Exp Med. 2001 Sep,195(1):21-33.
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