MYO3β, GST-tag Recombinant

Catalog #

40137

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant Human MYO3β (a.a. 1-326), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

myosin IIIB, myo3beta

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

63 kDa

Amino Acids

1–326

Genbank #

NM_138995

UniProt #

Q8WXR4

Tag(s)

N-terminal GST-tag

Background

MYO3β is a member of the Class III myosins that are actin-dependent motor proteins containing an amino-terminal kinase domain. MYO3β contains an N-terminal kinase domain, followed by motor, neck, and tail domains. The MYO3β gene generates a variety of splice variants that contain 1 or 2 calmodulin-binding (IQ) motifs in the neck domain and 1 of 3 domains in the tail domain. Northern blot analysis shows expression of a 7-kb MYO3β transcript in the human retina but not in a RPE cell line (1). The MYO3β gene transcript is also detected in the kidney, intestine and testis. The MYO3β gene maps to chromosome 2q31.1-q31.2 by genomic sequence alignment.

References

Dose, A C. et al: A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome. Genomics 79: 621-624, 2002.

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MYO3β, GST-tag Recombinant

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