MST4, GST-tag Recombinant
Catalog #
40134
$410
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Description
Recombinant human MST4, also known as MASK (GenBank Accession No. NM_016542), full length, with N-terminal GST tag, MW=72 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
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Synonyms
MASK; RP6-213H19.1
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Product Data Gallery
10% SDS-PAGE Coomassie Staining
Specific Activity
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
72 kDa
Amino Acids
full length
Specific Activity
23 pmol/min/µg
Genbank #
NM_016542
UniProt #
Q9P289
Background
MST4 belongs to a family of proteins that share similarity with a budding yeast serine/threonine kinase, sterile-20 (Ste20), and have a role in mitogen-activated protein kinase signaling during cytoskeletal rearrangement, morphogenesis, apoptosis, and other diverse cellular events (1). Expression of MST4 has been shown to correlate with tumorigenicity and inversely with androgen receptor status in a number of human prostate cancer cell lines. Overexpression of MST4 induced anchorage-independent growth and increased in vitro proliferation of these prostate cancer cell lines (2).
References
1. Dan, I. Et al: Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. J. Biol. Chem. 277: 5929-5939, 2002.
2. Sung, V. et al: The Ste20 kinase MST4 plays a role in prostate cancer progression. Cancer Res. 63: 3356-3363, 2003.
2. Sung, V. et al: The Ste20 kinase MST4 plays a role in prostate cancer progression. Cancer Res. 63: 3356-3363, 2003.
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