Metabolic Enzymes

 

Metabolic enzymes carry out a variety of cellular functions necessary for survival and homeostasis, including proteolysis and digestion, cellular respiration, energy storage, transcription, and response to the environment. These life-sustaining pathways are vital for growth and maintenance of cellular integrity. Metabolic enzymes encompass a wide range of different protein classes, including carboxylases, dehydrogenases, lipoxygenases, oxidoreductases, kinases, lyases, transferases, and more.

Disregulation of metabolic pathways has been linked to diabetes, obesity, hypertension, osteoporosis, hormonal disorders, cancer, and many other diseases. Given the importance of these essential pathways to cellular integrity and survival, it is not surprising that disregulation of delicate metabolic pathways has been linked to a number of human diseases. Targeting metabolic enzymes is of high interest in drug development programs for metabolic diseases such as diabetes, obesity and cancer. For example, Acetyl-coenzymes A (ACC1 and ACC2) are metabolic enzymes involved in fatty acid metabolism and is are attractive metabolic targets against diabetes and obesity. Phosphoglycerate Dehydrogenase (PHGDH) serves as a marker for aggressive breast cancer and melanoma. Nicotinamide Phosphoribosyltransferase (PBEF) regulates insulin secretion, making it a target for type 2 diabetes and tumor metastasis. ATP Citrate Lyase is required for histone acetylation and is highly upregulated in many cancer cells. HSPs are an ideal type of metabolic enzymes used for the study and effectiveness of cancer vaccines, the discovery of anticancer therapeutics, and the development of infectious disease treatments. Finally, Isocitrate Dehydrogenases (IDH1 & 2) are prominant markers for leukemia and brain tumors.

BPS’s portfolio of metabolic enzymes currently includes over 50 different enzymes and is continuously expanding.  Also, learn more about the Screening and Profiling Services for Metabolic Enzymes.

References:
1.    Hsu, P.P., et al., Cell. 2008. 134(5): 703-707.
2.    Maritim, A.C., et al., J. Biochem. Mol. Toxicol. 2003. 17(1): 24-38.

Metabolic Enzyme Subcategories

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Catalog#SizeProduct NamePrice
70021 100 µg Peroxiredoxin I (K197R), His-tag
$495
70010 100 µg Peroxiredoxin I, His-tag
$495
70011 100 µg Peroxiredoxin II, His-tag
$495
71089 50 µg PFKFB3, His-tag
$340
71199 50 µg PFKFB4, His-tag
$340
71079 100 µg PHGDH, His-tag
$340
40500 20 µg PKLR Var1 (PKR), His-tag
$455
40501 20 µg PKLR Var2 (PKL), His-tag
$455
40502 20 µg PKM1, His-tag
$455
71095 100 µg PPID (CYP-40), GST-tag
$340
71085 100 µg PSAT1, GST-tag
$340
50300 10 µg Sphingosine-1-phosphate lyase1, His-tag
$475
72000-1 20 µg T4 β-glucosyltransferase, His-tag
$90
72000-2 100 µg T4 β-glucosyltransferase, His-tag
$315
71195 50 µg TDO, His-tag (Human)
$325
71192 50 µg TPH1, His-tag (Human)
$310
71193 50 µg TPH2, His-tag (Human)
$310
27777-2 10 mg VER 155008
$170
27777-1 50 mg VER 155008
$355
27781-2 5 mg XL-888
$245
27781-3 25 mg XL-888
$545
27781-1 10 mg XL-888
$310

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