Metabolic Enzymes

 

Metabolic enzymes carry out a variety of cellular functions necessary for survival and homeostasis, including proteolysis and digestion, cellular respiration, energy storage, transcription, and response to the environment. These life-sustaining pathways are vital for growth and maintenance of cellular integrity. Metabolic enzymes encompass a wide range of different protein classes, including carboxylases, dehydrogenases, lipoxygenases, oxidoreductases, kinases, lyases, transferases, and more.

Disregulation of metabolic pathways has been linked to diabetes, obesity, hypertension, osteoporosis, hormonal disorders, cancer, and many other diseases. Given the importance of these essential pathways to cellular integrity and survival, it is not surprising that disregulation of delicate metabolic pathways has been linked to a number of human diseases. Targeting metabolic enzymes is of high interest in drug development programs for metabolic diseases such as diabetes, obesity and cancer. For example, Acetyl-coenzymes A (ACC1 and ACC2) are metabolic enzymes involved in fatty acid metabolism and is are attractive metabolic targets against diabetes and obesity. Phosphoglycerate Dehydrogenase (PHGDH) serves as a marker for aggressive breast cancer and melanoma. Nicotinamide Phosphoribosyltransferase (PBEF) regulates insulin secretion, making it a target for type 2 diabetes and tumor metastasis. ATP Citrate Lyase is required for histone acetylation and is highly upregulated in many cancer cells. HSPs are an ideal type of metabolic enzymes used for the study and effectiveness of cancer vaccines, the discovery of anticancer therapeutics, and the development of infectious disease treatments. Finally, Isocitrate Dehydrogenases (IDH1 & 2) are prominant markers for leukemia and brain tumors.

BPS’s portfolio of metabolic enzymes currently includes over 50 different enzymes and is continuously expanding.  Also, learn more about the Screening and Profiling Services for Metabolic Enzymes.

References:
1.    Hsu, P.P., et al., Cell. 2008. 134(5): 703-707.
2.    Maritim, A.C., et al., J. Biochem. Mol. Toxicol. 2003. 17(1): 24-38.

Metabolic Enzyme Subcategories

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Catalog#SizeProduct NamePrice
79123 100 μg MAT2B, His-Tag
$330
71096 50 µg MGLL, His-tag, GST-tag
$340
72041 96 reactions Mouse IDO1 Inhibitor Screening Assay Kit
$725
72042 96 reactions Mouse IDO2 Inhibitor Screening Assay Kit
$835
50296 20 µg Mouse PKM2, His-tag
$465
50305 50 µg MTAP, GST-tag
$475
73000 2 mg N-formylkynurenine
$370
71098 50 µg NAMPT (PBEF1)
$390
91004 50 µg NAMPT (PBEF1), GST-tag
$390
71276 96 reactions NAMPT Inhibitor Screening Assay Kit
$765
79307 384 reactions NAMPT Inhibitor Screening Assay Kit
$1,045
27071-1 1 mg ND-630
$350
27071-2 5 mg ND-630
$850
71090 100 µg NMNAT1, His-tag
$340
70015 10 µg NOS2, His-FLAG-tags
$475
70018 10 µg NOS3, His-FLAG-tag
$475
40084 10 µg PDHK1, GST-tag
$335
70020 100 µg Peroxiredoxin I (K197Q), His-tag
$495
70021 100 µg Peroxiredoxin I (K197R), His-tag
$495
70010 100 µg Peroxiredoxin I, His-tag
$495
70011 100 µg Peroxiredoxin II, His-tag
$495
71089 50 µg PFKFB3, His-tag
$340
71199 50 µg PFKFB4, His-tag
$340
71079 100 µg PHGDH, His-tag
$340
40500 20 µg PKLR Var1 (PKR), His-tag
$455

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