IDO2, His-Tag Recombinant
Recombinant human IDO2 (Indoleamine 2, 3-dioxygenase 2), encompassing amino acids 15-420(end). This construct contains an N-terminal His-tag (6xHis). The recombinant protein was affinity purified.
≥90%
20 mM Tris-HCl pH 7.5, 250 mM NaCl, 20% glycerol
L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells. The L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Indoleamine 2, 3- dioxygenases (IDO1 & IDO2), two of the rates limiting enzymes in this pathway, are upregulated in many tumors, providing cancer cells with an avenue for immune evasion. IDO2 is found mostly in the brain, liver, kidneys and placenta, and its levels can be regulated by IFNγ (interferon gamma), IL-10 and prostaglandin E2. Studies into the function of this protein and mechanism of action may prove essential for the development of effective cancer therapies.
1. Metz, R., et al., Canc. Res. 2007; 67(15): 7082-7087.
2. Witkiewicz, A.K., et al., J. Am. Coll. Surgeons. 2009; 208(5): 781-787.
3. Flick, H.E., et al., Int. Nat. J. Tryptophan Res. 2013; 6: 35-45.
Application Reference(s):
1. Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer (2019)
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