Tubastatin A hydrochloride

Catalog #: 27108
Size: 10 mg
$300
MW: 371.9 Da
CAS Registry #: 1310693-92-5
Formula: C20H21N3O2•HCl
Description:

Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 µM.

Purity:

≥98% by HPLC.

Biological Activity:
Inhibits HDAC6 with IC50 = 15 nM and HDAC1 with IC50 = 16.4 ┬ÁM.
Solubility:
Solubility in DMSO is 8 mg/ml, and in water and ethanol is < 1 mg/ml.
Format:
White to off-white crystalline solid; granular or powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):

1. Butler, K.V., et al. J Am Chem Soc. 2010; 132(31): 10842-6.

Application References: 
1. Histone deacetylase 6 (HDAC6) is an essential factor for oocyte maturation and asymmetric division in mice (2017)

Scientific Category:
HDAC
Product Type:
Inhibitor
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Product Datasheets

27108_Lot120327.pdf