Tubastatin A hydrochloride
Catalog #
27108
$310
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Description
Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 µM.
This product has been cited 4 times.
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Product Info
Storage and Usage
Citations4
Purity
≥98% by HPLC.
Format
White to off-white crystalline solid; granular or powder.
Formula
C20H21N3O2•HCl
MW
371.9 Da
Solubility
Solubility in DMSO is 8 mg/ml, and in water and ethanol is < 1 mg/ml.
Biological Activity
Inhibits HDAC6 with IC50 = 15 nM and HDAC1 with IC50 = 16.4 µM.
CAS Registry #
1310693-92-5
References
1. Butler, K.V., et al. J Am Chem Soc. 2010; 132(31): 10842-6.
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