Tubastatin A hydrochloride

Catalog #: 27108
Size: 10 mg
MW: 371.9 Da
CAS Registry #: 1310693-92-5
Formula: C20H21N3O2•HCl

Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 µM.


≥98% by HPLC.

Biological Activity:
Inhibits HDAC6 with IC50 = 15 nM and HDAC1 with IC50 = 16.4 ┬ÁM.
Solubility in DMSO is 8 mg/ml, and in water and ethanol is < 1 mg/ml.
White to off-white crystalline solid; granular or powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Butler, K.V., et al. J Am Chem Soc. 2010; 132(31): 10842-6.

Application References: 
1. Histone deacetylase 6 (HDAC6) is an essential factor for oocyte maturation and asymmetric division in mice (2017)

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