HDAC6, GST-Tag (Rat) Recombinant

Catalog #

101332

$440 *

Size: 50 µg

Qty

Bulk/Custom

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Description

Recombinant rat full length HDAC6 (Histone Deacetylase 6) encompassing amino acids 1-1152(end). The construct contains a N- terminal GST-Tag. This protein was affinity purified

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Synonyms

LOC103689963, LOC108348065, Hdac6, Histone deacetylase 6, HDAC-6

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

HDAC6 Activity

Product Info

Storage and Usage

Citations

Species

Rat

Construct

HDAC6 (GST-1-1152(end))

Host Species/Expression System

Sf9

Purity

≥80%

Format

Aqueous buffer solution.

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20 and 20% glycerol

156 kDa

Amino Acids

1-1152 (end)

Specific Activity

≥530 pmol/min/µg

Genbank #

XM_003752010.4

UniProt #

A0A0G2QC41

Tag(s)

N-Terminal GST Tag

Background

Histone Deacetylases (HDACs) are involved in histone deacetylation, which regulates transcription. HDAC6 is involved in multiple cellular processes, such as leptin sensitivity, cell motility, mitosis and stress granule formation. Overexpression of HDAC6 is linked to tumor formation, and mutations have been associated with Alzheimer’s disease. The use of HADC6 inhibitors presents high therapeutic potential for the treatment of neurodegenerative diseases and cancer.

Storage/Stability

At least 6 months at -80°C.

Assay Conditions

Assay was done according to HDAC6 Fluorogenic Assay Kit (BPS Bioscience #50076) with various amounts of HDAC6.

Instructions for Use

Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.

Applications

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Shipping Temperature

-80°C

Warnings

Avoid freeze/thaw cycles

Scientific Category

Deacetylases

Regulatory Status

Research Use Only