Acetyltransferase(s)

 

Acetyltransferases are enzymes that transfer an acetyl group from acetyl CoA to lysine amino acids. In the case of histone acetyltransferases (HATs), these lysine residues reside on histone tails. Generally, addition of acetyl groups to histone tails results in gene activation by inducing a euchromatin conformation and recruiting bromodomain-containing transcription factors for genes in close proximity to the acetylated histone. In a reaction mediated by deacetylase enzymes, such as histone deacetylases (HDACs) and sirtuins, the modification can be removed, thereby allowing for controlled, dynamic regulation of gene expression.

This control over HAT activity is disrupted in disease instances, such as cancer, where abnormal histone acetylation profiles have been shown to correlate with disease progression. Current work is being done to identify the specific epigenetic regulators that contribute to these aberrant acetylation profiles and, more importantly, to develop specific inhibitors and activators of these enzymes.

BPS has a large portfolio of acetyltransferase research tools. Our products include active purified enzymes, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our acetyltransferase products to ensure that we are producing only high-quality, consistent products.

References:

1.  Roth, S.Y., et al., Annu. Rev. Biochem. 2001; 70: 81-120.
2.  Dokmanovic, M. et al., Mol. Cancer Res. 2007; 5: 981-989. 

 

Acetyltransferase Subcategories

14 Item(s)

per page

Catalog#SizeProduct NamePrice
50079 96 reactions GCN5 Chemiluminescent Assay Kit
$435.00
50091 96 reactions GCN5 Fluorogenic Assay Kit
$425.00
50092 96 reactions P300 (KAT3B) Fluorogenic Assay Kit
$425.00
50077 96 reactions P300 Chemiluminescent Assay Kit
$435.00
50078 384 reactions P300 Homogeneous Assay Kit
$1,050.00
50095 20 ml 10x HAT Assay Buffer
$27.00
27049 25 mg AICAR
$115.00
91009-2 50 µg Angiopoietin-like 3, FLAG-tag (ANGPTL3 Protein)
$405.00
50072 50 µg ATAT1, GST-tag
$425.00
27613-2 50 mg C646
$485.00
27613-1 10 mg C646
$165.00
50074 50 µg GCN5 (KAT2A), FLAG-tag
$425.00
50096 20 ml HAT Stop Solution
$27.00
50071 50 µg p300 (KAT3B), His-GST-tags
$425.00

14 Item(s)

per page