Bromodomain

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

Items 1 to 25 of 142 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Catalog#SizeProduct NamePrice
27402 5 mg (+)-JQ1
$80.00
27401 1 mg (+)-JQ1
$42.00
27400 10 mg (+)-JQ1
$150.00
27334 5 mg (-)-JQ1
$130.00
27335 25 mg (-)-JQ1
$440.00
33007 10 ml 3x ATAD2 Assay Buffer
$170.00
33006 10 ml 3x ATAD2 Detection Buffer
$170.00
33001 10 ml 3x BRD Assay Buffer
$175.00
33002 10 ml 3x BRD Detection Buffer
$175.00
31147 100 µg ASH1L, His-tag
$295.00
32601 384 reactions ATAD2A Inhibitor Screening Assay Kit
$995.00
32618 384 reactions ATAD2A TR-FRET Assay Kit
$495.00
31121 100 µg ATAD2A, GST-tag
$295.00
31109 100 µg ATAD2A, His-tag
$295.00
31125 100 µg ATAD2B (KIAA1240), GST-tag
$295.00
31117 100 µg ATAD2B (KIAA1240), His-tag
$295.00
32605 384 reactions ATAD2B Inhibitor Screening Assay Kit
$995.00
32620 384 reactions ATAD2B TR-FRET Assay Kit
$495.00
31136 100 µg BAZ1A, GST-tag
$295.00
31137 100 µg BAZ1B, GST-tag
$295.00
31145 100 µg BAZ1B, His-tag
$295.00
32600 384 reactions BAZ2B Inhibitor Screening Assay Kit
$995.00
31113 100 µg BAZ2B, His-tag
$295.00
33000 0.5 ml @ 20 µM BET Bromodomain Ligand
$405.00
32521 384 reactions BRD1 Inhibitor Screening Assay Kit
$495.00

Items 1 to 25 of 142 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5