Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

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Catalog#SizeProduct NamePrice
32601 384 reactions ATAD2A Inhibitor Screening Assay Kit
$995.00
32618 384 reactions ATAD2A TR-FRET Assay Kit
$495.00
32605 384 reactions ATAD2B Inhibitor Screening Assay Kit
$995.00
32620 384 reactions ATAD2B TR-FRET Assay Kit
$495.00
32600 384 reactions BAZ2B Inhibitor Screening Assay Kit
$995.00
32632 384 reactions BPTF/FALZ TR-FRET Assay Kit
$995.00
32521 384 reactions BRD1 Inhibitor Screening Assay Kit
$495.00
32625 384 reactions BRD1 TR-FRET Assay Kit
$995.00
32614 384 reactions BRD2 (BD1+BD2) TR-FRET Assay Kit
$495.00
32522 384 reactions BRD2 (BD2) Inhibitor Screening Assay Kit
$495.00
32513 384 reactions BRD3 (BD1) Inhibitor Screening Assay Kit
$495.00
32615 384 reactions BRD3 (BD1+BD2) TR-FRET Assay Kit
$495.00
32523 384 reactions BRD3 (BD2) Inhibitor Screening Assay Kit
$495.00
32514 384 reactions BRD4 (BD1) Inhibitor Screening Assay Kit
$495.00
32613 384 reactions BRD4 (BD1) TR-FRET Assay Kit
$495.00
32612 384 reactions BRD4 (BD1+BD2) TR-FRET Assay Kit
$495.00
32524 384 reactions BRD4 (BD2) Inhibitor Screening Assay Kit
$495.00
32617 384 reactions BRD4 (BD2) TR-FRET Assay Kit
$495.00
32519 384 reactions BRD9 (BD1) Inhibitor Screening Assay Kit
$495.00
32621 384 reactions BRD9 TR-FRET Assay Kit
$495.00
32616 384 reactions BRDT (BD1+BD2) TR-FRET Assay Kit
$495.00
32608 384 reactions BRPF3 Inhibitor Screening Assay Kit
$995.00
32626 384 reactions BRPF3 TR-FRET Assay Kit
$995.00
32611 384 reactions CECR2 Inhibitor Screening Assay Kit
$995.00
32622 384 reactions CECR2 TR-FRET Assay Kit
$495.00

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