TAOK1, GST-tag Recombinant

Catalog #

40283

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human TAOK1 (a.a. 1-314), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

PSK2, MARKK, MAP3K16, FLJ14314, KIAA1361

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥90%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

63 kDa

Amino Acids

1–314

Genbank #

NM_020791

UniProt #

Q7L7X3

Tag(s)

N-terminal GST-tag

Background

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs) (1). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay (2).

References

1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273(44):28625-32.
2. Draviam, V.M. et al: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat. Cell Biol. 2007; 9(5):556-64.

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TAOK1, GST-tag Recombinant

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