Cholesterol Screening and Profiling

Accelerate your drug discovery program with PCSK9 Screening and Profiling Services from BPS Bioscience, Inc. Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy to:

  • Screen for inhibitors/targets using our PCSK9 assays
  • Select from IC50 determination and single point concentrations
  • Receive data within days of compound submission
  • Perform follow-up studies using the same proteins manufactured in-house
  • Get questions answered or project guidance in a time-efficient manner

Background:

PCSK9 is a critical regulator of cholesterol metabolism through its interaction with the hepatic LDL receptor (LDLR). PCSK9 is a kexin (that is,an endopeptidase) found in kidneys, liver, and intestine.  It binds to the EGFR-like domain of LDLR, leading to LDLR degradation. Circulating PCSK9 binds to the extracellular EGF-like domain of LDLR, followed by endocytosis and lysosomal degradation of the PCSK9-LDLR complex. Inhibiting the PCSK9-LDLR interaction is an increasingly desirable drug target for lowering LDL-cholesterol levels because of the great demand for new drugs to replace or supplement statins.  The newly added research tools are invaluable for studying cholesterol metabolism, atherosclerosis, stroke, heart disease, and other diseases related to cardiovascular disorders. Specifically, BPS' PCSK9 neutralizing antibody, useful as a positive control for inhibition. 

BPS Bioscience offers PCSK9 and LDLR proteins, Binding Assay Kits, and PCSK9 Screening/Profiling Services for cholesterol related research. Interested in high throughput screening? Our PCSK9 assay kit is also available in a convenient, homogeneous TR-FRET format. Check this out along with the mutant (D374T) PCSK9 protein and mutant (D374T) PCSK9 assay kit which causes increased affinity of PCSK9 for the LDLR substrate.

 

Related technologies:

  • Chemiluminescent

Contact us today for more information about our Screening and Profiling Services. Tailor our services to meet your needs: Learn more about our Custom Services.

Not quite what you’re looking for? Our Custom Assay Development Services allow for flexibility to meet your specific research needs