c-RAF, GST-Tag Recombinant
Recombinant human c-RAF (Raf-1 proto-oncogene, serine/threonine kinase (RAF1)), encompassing amino acids 50-140. This construct contains an N-terminal GST-tag followed by a PreScission site. The recombinant protein was affinity purified.
≥90
Aqueous buffer solution.
40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
c-Raf, also known as Raf-1 or proto-oncogen c-Raf, is a member of the Raf (rapidly accelerated fibrosarcoma) kinase family. C-Raf is ubiquitously expressed and seems to be essential for embryogenesis and survival. It plays a role in cell proliferation, differentiation, apoptosis, and senescence. It phosphorylates MEK1/2 (MAP kinase kinase 1/2), resulting in ERK1/2 (extracellular signal-regulated kinase 1/2) activation. It is involved in cancer, by mediating cell proliferation and transformation. C-Raf is an attractive therapeutic target, and agents targeting this protein are currently being investigated in clinical trials for oncologic disorders.
1. Rooij, J., et al., Oncogene. 1997;14:623-625.
2. Bhaswati, P., et al., Nature Genetics. 2007;39:1007-1012.
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