MINK1, GST-tag Recombinant

Catalog #

40126

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human MINK1 (a.a. 1-320), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

B55; ZC3; MINK; YSK2; hMINK; MAP4K6; MGC21111; hMINKβ

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

61 kDa

Amino Acids

1–320

Genbank #

NM_015716

UniProt #

Q8N4C8

Tag(s)

N-terminal GST-tag

Background

MINK1 is a member of the germinal center family of kinases that are homologous to the Ste20 family and regulate a wide variety of cellular processes, including cell morphology, cytoskeletal rearrangement, and survival (1). Overexpression of kinase-dead mutants of MINK1 leads to enhanced cell spreading, actin stress fiber formation, adhesion to extracellular matrix and decreased cell motility and invasion. MINK is activated after Ras induction via a mechanism involving reactive oxygen species and mediates stimulation of p38 MAPK downstream of the Raf/ERK pathway (2).

References

1. Hu, Y. et al: Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. J Biol Chem. 2004 Dec 24;279(52):54387-97.
2. Nicke, B. et al: Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell. 2005 Dec 9;20(5):673-85.

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MINK1, GST-tag Recombinant

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