Metabolic Enzymes

 

Metabolic enzymes carry out a variety of cellular functions necessary for survival and homeostasis, including proteolysis and digestion, cellular respiration, energy storage, transcription, and response to the environment. These life-sustaining pathways are vital for growth and maintenance of cellular integrity. Metabolic enzymes encompass a wide range of different protein classes, including carboxylases, dehydrogenases, lipoxygenases, oxidoreductases, kinases, lyases, transferases, and more.

Disregulation of metabolic pathways has been linked to diabetes, obesity, hypertension, osteoporosis, hormonal disorders, cancer, and many other diseases. Given the importance of these essential pathways to cellular integrity and survival, it is not surprising that disregulation of delicate metabolic pathways has been linked to a number of human diseases. Targeting metabolic enzymes is of high interest in drug development programs for metabolic diseases such as diabetes, obesity and cancer. For example, Acetyl-coenzymes A (ACC1 and ACC2) are metabolic enzymes involved in fatty acid metabolism and is are attractive metabolic targets against diabetes and obesity. Phosphoglycerate Dehydrogenase (PHGDH) serves as a marker for aggressive breast cancer and melanoma. Nicotinamide Phosphoribosyltransferase (PBEF) regulates insulin secretion, making it a target for type 2 diabetes and tumor metastasis. ATP Citrate Lyase is required for histone acetylation and is highly upregulated in many cancer cells. HSPs are an ideal type of metabolic enzymes used for the study and effectiveness of cancer vaccines, the discovery of anticancer therapeutics, and the development of infectious disease treatments. Finally, Isocitrate Dehydrogenases (IDH1 & 2) are prominant markers for leukemia and brain tumors.

BPS’s portfolio of metabolic enzymes currently includes over 50 different enzymes and is continuously expanding.  Also, learn more about the Screening and Profiling Services for Metabolic Enzymes.

References:
1.    Hsu, P.P., et al., Cell. 2008. 134(5): 703-707.
2.    Maritim, A.C., et al., J. Biochem. Mol. Toxicol. 2003. 17(1): 24-38.

Metabolic Enzyme Subcategories

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Catalog#SizeProduct NamePrice
100104 10 μg ACC, FLAG-Tag (Candida albicans)
$475
50202 10 µg ACC1, FLAG-His-tags
$475
50200 10 µg ACC1, His-tag
$475
50201 10 µg ACC2, His-tag
$475
79315 96 reactions Acetyl-Coenzyme A Carboxylase 1 (ACC1) Assay Kit
$725
79282 96 reactions Acetyl-Coenzyme A Carboxylase 2 (ACC2) Assay Kit
$725
70016 100 µg Adenosine Deaminase (ADA), His-tag
$475
70017 50 µg  AHCY, S. solfataricus, His-tag
$475
50270 100 µg ALAS2, His-tag
$475
50220 20 µg ALOX15, FLAG-tag
$455
27730-1 25 mg Alvespimycin HCl (17-DMAG)
$160
27730-2 100 mg Alvespimycin HCl (17-DMAG)
$320
72048 384 reactions ARG1 Inhibitor Screening Assay Kit
$1,095
71658 50 μg ARG1, His-Tag
$455
72043 384 reactions ARG2 Inhibitor Screening Assay Kit
$1,095
71659 50 μg ARG2, His-Tag
$455
50255 10 µg ATP Citrate Lyase, GST-tag
$475
71093 100 µg Carbonic Anhydrase 1 (CA1), His-tag
$465
71094 100 µg Carbonic Anhydrase 2 (CA2), His-tag
$465
71101 100 µg Carbonic Anhydrase 9 (CA9), His-tag
$465
71110

100 µg
1 mg

COX1, FLAG-His-tags
Starting at:
$455
71111 100 µg COX2, FLAG-His-tags
$455
27619-1 1 g Donepezil HCl
$140
27619-2 5 g Donepezil HCl
$295
27749-2 50 mg Ezetimibe
$165

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