Metabolic Enzymes

 

Metabolic enzymes carry out a variety of cellular functions necessary for survival and homeostasis, including proteolysis and digestion, cellular respiration, energy storage, transcription, and response to the environment. These life-sustaining pathways are vital for growth and maintenance of cellular integrity. Metabolic enzymes encompass a wide range of different protein classes, including carboxylases, dehydrogenases, lipoxygenases, oxidoreductases, kinases, lyases, transferases, and more.

Disregulation of metabolic pathways has been linked to diabetes, obesity, hypertension, osteoporosis, hormonal disorders, cancer, and many other diseases. Given the importance of these essential pathways to cellular integrity and survival, it is not surprising that disregulation of delicate metabolic pathways has been linked to a number of human diseases. Targeting metabolic enzymes is of high interest in drug development programs for metabolic diseases such as diabetes, obesity and cancer. For example, Acetyl-coenzymes A (ACC1 and ACC2) are metabolic enzymes involved in fatty acid metabolism and is are attractive metabolic targets against diabetes and obesity. Phosphoglycerate Dehydrogenase (PHGDH) serves as a marker for aggressive breast cancer and melanoma. Nicotinamide Phosphoribosyltransferase (PBEF) regulates insulin secretion, making it a target for type 2 diabetes and tumor metastasis. ATP Citrate Lyase is required for histone acetylation and is highly upregulated in many cancer cells. HSPs are an ideal type of metabolic enzymes used for the study and effectiveness of cancer vaccines, the discovery of anticancer therapeutics, and the development of infectious disease treatments. Finally, Isocitrate Dehydrogenases (IDH1 & 2) are prominant markers for leukemia and brain tumors.

BPS’s portfolio of metabolic enzymes currently includes over 50 different enzymes and is continuously expanding.  Also, learn more about the Screening and Profiling Services for Metabolic Enzymes.

References:
1.    Hsu, P.P., et al., Cell. 2008. 134(5): 703-707.
2.    Maritim, A.C., et al., J. Biochem. Mol. Toxicol. 2003. 17(1): 24-38.

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Catalog#SizeProduct NamePrice
50202 10 µg ACC1, FLAG-His-tags
$455
50200 10 µg ACC1, His-tag
$455
50201 10 µg ACC2, His-tag
$455
50203 10 µg ACC2, His-tag, Strep-tag
$455
70016 100 µg Adenosine Deaminase (ADA), His-tag
$435
70017 50 µg  AHCY, S. solfataricus, His-tag
$435
50270 100 µg ALAS2, His-tag
$435
50220 20 µg ALOX15, FLAG-tag
$415
27730-2 100 mg Alvespimycin HCl (17-DMAG)
$320
27730-1 25 mg Alvespimycin HCl (17-DMAG)
$160
71658 50 μg ARG1, His-Tag
$415
71659 50 μg ARG2, His-Tag
$415
50255 10 µg ATP Citrate Lyase, GST-tag
$435
71093 100 µg Carbonic Anhydrase 1 (CA1), His-tag
$425
71094 100 µg Carbonic Anhydrase 2 (CA2), His-tag
$425
71101 100 µg Carbonic Anhydrase 9 (CA9), His-tag
$425
71110 100 µg COX1, FLAG-His-tags
$415
71111 100 µg COX2, FLAG-His-tags
$415
27619-2 5 g Donepezil HCl
$290
27619-1 1 g Donepezil HCl
$127
27749-2 50 mg Ezetimibe
$195
27749-3 100 mg Ezetimibe
$220
27749-1 25 mg Ezetimibe
$110
71076 100 μg FDH, P. putida, His-tag
$309
71077 10 µg Fucokinase, FLAG-tag
$435

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