ACC1, His-Tag Recombinant
Recombinant human ACC1 (acetyl-coenzyme A carboxylase 1), encompassing amino acids 1-2383(end). This construct includes a C-terminal His-tag (10xHis). This protein was affinity purified.
≥65%
Aqueous buffer solution.
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, and variable Imidazole
≥58 pmol/min/µg
ACC1 (acetyl-coenzyme A carboxylase 1) is one of two isoforms of acetyl-CoA carboxylase. It is a cytosolic and it is involved in ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in de novo fatty acid synthesis, and it is found predominantly in the liver and adipose tissue. Its function is regulated by phosphorylation, allosteric regulators and other proteins, in response to the energetic needs of cells. Acetyl-CoA is at the crossroads between multiple metabolic pathways, so ACC1 has an impact in the formation of building blocks for new cells and in the response to metabolic stress. ACC1 has been linked to several diseases, such as cancer, diabetes, NAFLD (non-alcholic fatty liver disease) and obesity. Inhibition of ACC1 by TOFA (5-tetradecyloxy-2-furoic acid) can result in complete blockage of DNL (de novo lipogenesis) and may be a potential therapy for patients with NAFLD. The development of inhibitors specific for ACC1, for instance by targeting their catalytic domains or dimerization, may prove beneficial in the treatment of ACC1-related diseases.
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