Heat Shock Protein

Heat shock proteins are present in cells under normal conditions, but are expressed at much higher levels under conditions of stress, such as pH change, oxygen deprivation, and heat. They function as molecular chaperones by stabilizing denatured proteins that have become misfolded or unfolded as a result of cellular stress and by aiding in their re-folding. Left uncorrected, these misfolded proteins can form aggregates that eventually can kill the cell.

Two isoforms of heat shock proteins, HSP90α and HSP90β, are integral to the folding and stabilization of over 50 proteins directly related to tumor growth, making HSP90 a promising target for the development of anti-cancer therapeutics. HSP90 inhibitors that bind the N-terminal, ATP binding pocket of HSP90 have resulted in a number of first and second generation anti-cancer drugs. Evidence suggests that targeting the C-terminal domain will lead to the identification of new and innovative drug candidates.

BPS’ portfolio of HSPs includes the first domain-specific HSP90 assay kits, enabling researchers to differentiate between inhibitors of the N- and C terminal domains of HSP90α and HSP90β. In addition to assay kits, BPS also offers purified HSP proteins, inhibitors, and screening and profiling services for HSP90 inhibitors.

References:

1. Kamal, A. et al., Nature, 2003; 425: 407-410.
2. Neckers, L., et al., Trends Mol. Med. 2002; 8: S55-S61.

Heat Shock Protein Subcategories

19 Item(s)

per page

Catalog#SizeProduct NamePrice
50317 384 reactions HSP90α (C-Terminal) Inhibitor Screening Assay Kit
$925
50298 384 reactions HSP90α (N-terminal) Assay Kit
$925
50293 96 reactions HSP90α N-Terminal Domain Assay Kit
$435
50294 96 reactions HSP90β N-Terminal Domain Assay Kit
$435
50324 10 mL 3x HSP90 Assay Buffer 2
$165
50311 20 ml 5x HSP90 Assay Buffer 1
$165
50322 100 µg Hop/STIP1, FLAG-tag
$309
50285 100 µg HSP40, His-tag
$405
50288 100 µg HSP70 (Q435A), His-tag
$435
50287 200 µg HSP70, His-tag
$375
50261 384 reactions HSP90α (C-Terminal Domain) TR-FRET Kit
$1,025
50316 100 µg HSP90α (C-terminal), Biotin-labeled, His-tag, Avi-tag
$450
50289 96 reactions HSP90α C-Terminal Domain TR-FRET Assay Kit
$695
50290 200 µg HSP90α, His-tag
$385
50262 384 Reactions HSP90β (C-Terminal Domain) TR-FRET Kit
$1,025
50314 384 reactions HSP90β (C-terminal) Inhibitor Screening Kit
$925
50313 100 µg HSP90β (C-terminal), Biotin-labeled, His-tag, Avi-tag
$450
50299 384 reactions HSP90β (N-terminal) Assay Kit
$925
50292 200 µg HSP90β, His-tag
$385

19 Item(s)

per page