Ganetespib (STA-9090)
Catalog #
27750-1
$250
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Description
Ganetespib (also known as STA-9090) is a potent small-molecule inhibitor of heat shock protein 90 (IC50=4 nM). It binds to the ATP pocket in the N-terminus of Hsp90, resulting in down-regulation of Hsp90 client protein levels. Being structurally unrelated to geldanamycin-derived Hsp90 inhibitors (17-AAG, 17-DMAG, and IPI-504), ganetespib has a unique triazolone-containing chemical structure and stands out other Hsp90 inhibitors in terms of potency, antitumor activity, and safety profile.
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Synonyms
Ganetespib; STA-9090; STA 9090
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Product Data Gallery
Product Info
Storage and Usage
Citations
Target(s)
HSP90
Formula
C20H20N4O3
MW
364.4 Da
Solubility
Soluble in DMSO
Biological Activity
Ganetespib exhibits antitumor activity against a broad range of human cancers, including lung cancer, prostate cancer, colon cancer, breast cancer, melanoma and leukemia.
CAS Registry #
888216-25-9
References
1. Ying, W., et al. Mol Cancer Ther 2012; 11: 475-484.
2. Goldman, J.W., et al. BMC Cancer 2013; 13:152
2. Goldman, J.W., et al. BMC Cancer 2013; 13:152
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