17-AAG
Catalog #
27027
$190
*
●
●
Purchase
Description
17-AAG binds specifically to heat shock protein Hsp90 in a manner similar to geldanamycin, but the binding is weaker. Inhibits Akt activation and HER2 expression in tumor cells. Exhibits 100-fold higher binding affinity for tumor-cell-derived hsp90 over that derived from normal cells. Inhibits angiogenesis.
●
Synonyms
17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin
●
Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥99%
Format
Purple solid
Formula
C31H43N3O8
MW
585.7 Da
Solubility
Soluble in DMSO at 150 mg/mL and ethanol 5 mg/mL. Poorly soluble in H2O.
CAS Registry #
75747-14-7
References
1. Basso, A.D., et al. Oncogene 21: 1159-1166 (2002).
2. Schulte, T.W. and Neckers, L.M. Cancer Chemother. Pharmacol. 42: 273-279 (1998).
3. Kaur, G, et al. Clin. Cancer Res. 10: 4813-4821 (2004).
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.