Heat Shock Protein Screening & Profiling

The HSP70 and HSP90 families of chaperone proteins help to process hundreds of proteins that are crucial in a myriad of cellular processes, including cell cycle control, cell signaling, cell survival, and apoptosis. In diseases such as cancer, they provide critical support for proteins responsible for tumorigenic pathways, such as signaling kinases, transcription factors, epigenetic regulators, and metabolic enzymes. Thus, HSP70 and HSP90 inhibitors show promise as therapeutics, but improved drugs with better toxicity, drug-resistance, and pharmacokinetic profiles are still required.

We offer HSP90α and HSP90β screening and profiling services that enable identification of N-terminal or C-terminal specific inhibitors, while our HSP70 screening service identifies inhibitors of ATP hydrolysis. Our team of experts, using our in-house developed biochemical assay kits, can provide:

• Screening for activity across your compound library
• Determination of IC₅₀
• Project guidance and questions answered in a timely manner
• Delivery of detailed results promptly and on time