Geldanamycin
Catalog #
27008
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Description
Geldanamycin is an antibiotic and a potent antitumor compound. It inhibits pp60src tyrosine kinase, and it also binds specifically to heat shock protein Hsp90 and its GP96 homologue. It is known to inhibit protein maturation.
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Product Info
Storage and Usage
Citations
Purity
≥95% by HPLC.
Format
Diluted in DMSO
Concentration
10 mM
Formula
C29H40N2O9
MW
560.6 Da
Solubility
Soluble in anhydrous DMSO at 100 mg/ml. Poorly soluble in methanol. Ethanol and water are not recommended for stock solutions. The maximum water solubility is estimated to be ~ 20 –
50 µM.
Biological Activity
Geldanamycin strongly inhibited Hsp90 protein as shown through inhibited Plasmodium falciparum growth in human erythrocyte culture with an IC50 of 20 nM.
CAS Registry #
30562-34-6
References
1. Whitesell, L. and Cook, P. Mol. Endocr. 10: 705 – 712 (1996)
2. Rajinder, K., et al., Malaria Journal 2:30 (2003)
2. Rajinder, K., et al., Malaria Journal 2:30 (2003)