EX527

Catalog #: 27103
Size: 1 mg
$180
MW: 248.7 Da
CAS Registry #: 49843-98-3
Formula: C13H13ClN2O
Description:
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor. It is Selective inhibitor of SIRT1 that does not class I/II inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation.
Purity:

≥99% by HPLC

Biological Activity:
EX-527 inhibits SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. IC50 values are 98 nM, 19.6 µM, 48.7 µM, >100 µM and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively.
Solubility:
Soluble in DMSO.
Format:
White to beige powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):

1. Solomon, JM et al. Mol Cell Biol. 2006 Jan;26(1):28-38
2. Huhtiniemi, T et al. J Med Chem. 2008 Aug 14;51(15):4377-80

Application Reference(s):
1. Cyclocarya paliurus extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion (2017)

Scientific Category:
HDAC
Product Type:
Inhibitor
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Product Datasheets

27103_Lot111121.pdf