EPHB3, GST-tag Recombinant

Catalog #

40186

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human EPHB3 (a.a. 585-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

ETK2; HEK2; Cek10; Mdk5; TYRO6, Ephrin Type A Receptor 1, EPHB-3

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

68 kDa

Amino Acids

585–end

Genbank #

NM_004443

UniProt #

P54753

Tag(s)

N-terminal GST-tag

Background

EPHB3 is a member of the Ephrin receptor family and is expressed during embryonic development in multiple regions of the central nervous system. In adult brain, EPHB3 is expressed in the cerebellum, raphe pallidus, hippocampus, entorhinal cortex, and both motor and sensory cortices (1). EPHB3 is involved in the maintenance of mature neuronal connections and/or re-arrangement of synaptic connections during late stages of development. EPHB3 plays a role in the regulation of cell adhesion and migration, and the catalytic activity of EPHB3 is required for inhibition of integrin-mediated cell adhesion (2).

References

1. Willson, CA. et al: EphB3 receptor and ligand expression in the adult rat brain. J Mol Histol. 2006 Nov;37(8-9):369-80.
2. Miao, H. et al: Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem. 2005 Jan 14;280(2):923-32.

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EPHB3, GST-tag Recombinant

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