EPHA3, GST-tag Recombinant

Catalog #

40192

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human EPHA3 (a.a. 571-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

ETK, HEK, ETK1, HEK4, TYRO4, Ephrin Type A Receptor 3, EPHA-3

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥90%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

72 kDa

Amino Acids

571–end

Genbank #

BC063282

UniProt #

Q6P4R6

Tag(s)

N-terminal GST-tag

Background

EPHA3 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. Analysis of human colorectal, breast, lung and pancreatic cancer samples shows somatic mutations in the EPHA3 gene (1). EPHA3 gene expression can be regulated by CD28 and IGF-1 in Jurkat cells and expression of EPHA3 is associated with adherence and motility of malignant T cells (2).

References

1. Wood, L D. et al: Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat. 2006 Oct;27(10):1060-1.
2. Smith, L M. et al: EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. Exp Cell Res. 2004 Jan 15;292(2):295-303.

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EPHA3, GST-tag Recombinant

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