AGK2

Catalog #

27228

$165 *

Size: 5 mg

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Description

AGK2 is a selective, cell-permeable inhibitor of SIRT2. It has minimal effects SIRT1 and SIRT3 at 10-fold higher levels compared to SIRT2. Useful for studing SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Format

A crystalline solid.

Formula

C₂₃H₁₃Cl₂N₃O₂

434.3 Da

Solubility

Soluble in DMSO and DMF purged with an inert gas. Solubility is approximately 1 mg/ml in DMSO and approximately 3 mg/ml in DMF.

Biological Activity

AGK2 inhibits SIRT2 with an IC50 value of 3.5 µM.

CAS Registry #

304896-28-4

References

Outeiro, T.F., et al., Science. 2007;317:516-519.

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