CBL-B (Y363F), His-tag, Biotin-labeled (Human) Recombinant
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Catalog #
80413
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Description
Human Casitas B-lineage lymphoma proto-oncogene b (CBL-B), also known as E3 ubiquitin-protein ligase CBL-B, RING finger protein 56, and SH3- binding protein CBL-B with Y363F mutation GenBank Accession No. NM_170662, a.a. 39 – 426 with N-terminal His-tag and N-terminal Avi-tag, expressed in an E. coli expression system. This protein was enzymatically biotinylated in vivo using AviTagTM technology. MW=48 kDa.
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Synonyms
E3 ubiquitin-protein ligase CBL-B, RING finger protein 56, SH3-binding protein CBL-B with Y363F mutation, CBL, CBLB
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
4-20% SDS-PAGE Anti-His Western
4-20% SDS-PAGE Streptavidin western
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥85%
Format
Aqueous buffer solution
Formulation
40 mM Hepesl, pH 7.4, 120
mM NaCl, 20% glycerol, 200 mM imidazole
MW
48 kDa
Amino Acids
39 – 426
Genbank #
NM_170662
UniProt #
Q13191
Background
CBL-B, a RING finger E3-ubiquitin ligase, acts as an intracellular checkpoint and a regulator of cytotoxic lymphocytes and NK cells. CBL-B binds E2-ubiqutin as well as target proteins such as TAM receptor TYRO3, forcing further degradation of TYRO3. CBL-B modulates innate immune responses and plays a key role in host defense to pathogens and anti-tumor immunity. Targeting CBL-B represents a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. CBL-B has emerged as a new target of interest in the field of immunotherapy due to its ability to suppress cancer immune-evasion. CBL-B initiates anti-cancer immune responses in NK cells in both cytotoxic and effector T cells, promoting T-cell and NK cell activation.
References
1. Jeon, M.S., et al., Immunity. 2004; 21(2):
167-177.
2. Chiang, Y.J. et al., Nature. 2000; 403: 216-220.
2. Chiang, Y.J. et al., Nature. 2000; 403: 216-220.
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