Catalog #: 27731
Size: 25 mg
MW: 420.4 Da
CAS Registry #: 317-34-0
Formula: C16H24N10O4
Target: PDE
Aminophylline is a bronchodilator that is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases. Aminophylline is also a competitive adenosine receptor antagonist and it is thought to have potential therapeutic value for cardiac ischemia.
Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.
theophylline ethylenediamine; bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine
Soluble in water (3.7 mg/ml). Solutions should be freshly prepared. Not soluble in alcohols.
white to off-white powder
Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Crisanti, et al., Am. J. Physiol. 277, R829-R835, (1999).
2. Chanda, et al., Pol. J. Pharmacol. 50, 80-82, (1998).
3. Thakker, et al. Analytical Profiles of Drug Substances 2nd ed., (1982) 2, 1-44.
Scientific Category:
PDE Inhibitor
Product Type:
Data shown is lot-specific. Contact us for specific information on other lots.

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