Aminophylline

Catalog #: 27731
Size: 25 mg
$195
MW: 420.4 Da
CAS Registry #: 317-34-0
Formula: C16H24N10O4
Target: PDE
Background:
Aminophylline is a bronchodilator that is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases. Aminophylline is also a competitive adenosine receptor antagonist and it is thought to have potential therapeutic value for cardiac ischemia.
Description:
Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.
Synonym(s):
theophylline ethylenediamine; bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine
Solubility:
Soluble in water (3.7 mg/ml). Solutions should be freshly prepared. Not soluble in alcohols.
Format:
white to off-white powder
Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s):
1. Crisanti, et al., Am. J. Physiol. 277, R829-R835, (1999).
2. Chanda, et al., Pol. J. Pharmacol. 50, 80-82, (1998).
3. Thakker, et al. Analytical Profiles of Drug Substances 2nd ed., (1982) 2, 1-44.
Scientific Category:
PDE Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.

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