SRPK1, GST-tag Recombinant

Catalog #

40277

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human serine/arginine domain protein kinase 1 (SRPK1), full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

SFRSK1

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

130 kDa

Amino Acids

full length

Genbank #

BC038292

UniProt #

Q96SB4

Tag(s)

N-terminal GST-tag

Background

SRPK1 is a Ser/Thr protein kinase that has sequence and function similar to SRPK2. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin (1). SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro. Hence it is believed that SRPK1 plays a key role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors (2).

References

1. Hayes, G.M. et al: Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas. Cancer Res. 2007;67(5):2072-80.
2. Gui, J.-F. et al: A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 369: 678-682, 1994.

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SRPK1, GST-tag Recombinant

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