SOK1, GST-tag Recombinant

Catalog #

40276

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human SOK1, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

STK25, YSK1, DKFZp686J1430

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

76 kDa

Amino Acids

full length

Genbank #

NM_006374

UniProt #

O00506

Tag(s)

N-terminal GST-tag

Background

SOK1 or oxidant stress-response kinase-1 is a serine/threonine kinase that is activated by autophosphorylation and by reactive oxygen intermediates, but is not activated by growth factors, alkylating agents, cytokines, or environmental stresses (1). SOK1 is expressed ubiquitously with highest expression in brain and testis. SOK1 regulates cell death after chemical anoxia, as its down-regulation by RNA interference enhances cell survival. SOK1 entry into the nucleus is important for the cell death response since SOK1 mutants unable to enter the nucleus do not induce cell death (2).

References

1. Pombo, C M. et al: Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J. 15: 4537-4546, 1996.
2. Nogueira, E. et al: SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. J Biol Chem. 2008 Jun 6; 283(23):16248-58.

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SOK1, GST-tag Recombinant

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