SMER3
Catalog #
27718-1
$250
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Description
Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. Cell permeable. Significant inhibition is typically seen at 30-100 μM.
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Synonyms
9H–Indeno[1,2–e][1,2,5]oxadiazolo[3,4–b]pyrazin–9–one
Product Info
Storage and Usage
Citations
Purity
>98% by TLC.
Format
Yellow powder
Formula
C11H4N4O2S
MW
224.2 Da
Solubility
Soluble in DMSO (up to 20 mg/ml, with heating)
CAS Registry #
67200-34-4
References
Aghajanyy, M. et al. Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat. Biotech. 2010, 28(7):738.
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