Obatoclax

Catalog #

27044

$120 *

Size: 5 mg

Qty

Bulk/Custom

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Description

Obatoclax also known as GX15-070, is a synthetic derivative of bacterial prodiginines and acts as small molecule antagonist against anti-apoptotic Bcl2 (B-cell lymphoma 2) family members. It's considered a pro-apoptotic BH3 death domain mimetic. It functions as a competitive inhibitor by binding to the hydrophobic pocket of anti-apoptotic BCL2 family members such as BCL-2, BCL-XL, BCL-W, and MCL-1, thereby causing BAX/BAK activation to induce apoptosis. However, there’s no evidence to show direct interaction of Obatoclax with the BH3 domain in biochemical settings.

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Synonyms

GX15-070, Obatoclax mesylate

Product Info

Storage and Usage

Citations

Purity

≥99%

Format

Brown powder

Formula

C₂₀H₁₉N₃O•CH₄SO₃

413.5 Da

Solubility

Soluble in DMSO at 5 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 200-400 µM

CAS Registry #

803712-79-0

References

1. Chonghaile, T.N. and Letai, A. Oncogene 27: S149-S157 (2008).
2. Konopleva, M., et al. Cancer Res. 68: 3413-3420 (2008).
3. Nguyen, M., et al. Proc. Natl. Acad. Sci. USA 104: 19512-19517 (2007).

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Obatoclax

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