Pimobendan

Catalog #
27638-1
$300 *
Size: 10 mg
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Description

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 µM.

Synonyms
pimobendane; 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Product Info
Storage and Usage
Citations
Target(s)
PDE3
Formula
C19H18N4O2
MW
334.37 Da
Biological Activity
Pimobendan exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s>30 µM). Pimobendan inhibits the activity of cAMP-PDE III with IC50 of 2.4 µM.
CAS Registry #
74150-27-9
References
Boyle KL, Leech E. J Vet Emerg Crit Care (San Antonio). 2012 Aug;22(4):398-408.