IBMX

Catalog #

27213

$115 *

Size: 100 mg

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Description

IBMX, also known as 1-Methyl-3-Isobutylxanthine and Isobutylmethylxanthine, is a widely-used inhibitor of cAMP and cGMP PDEs. It has been shown that the increase in cellular cAMP and cGMP levels, resulting from the inhibition of PDEs by IBMX, activates cyclicnucleotide-regulated protein kinases. IBMX does not inhibit PDE8A, PDE8B, or PDE9.

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Format

A crystalline solid.

Formula

C₁₀H₁₄N₄O₂

222.3 Da

Solubility

Solubility in ethanol is ~5 mg/ml and DMSO is ~10 mg/ml. For biological experiments, dilute the organic solvent into aqueous buffers or isotonic saline.

Biological Activity

IBMX inhibits PDEs as listed below.
PDE     IC50:
PDE1     19 µM
PDE2     50 µM
PDE3     18 µM
PDE4     13 µM
PDE5     32 µM
PDE7     7 µM
PDE11     50 µM

CAS Registry #

28822-58-4

References

1. Fawcett, L., et al., Proc. Natl. Acad. Sci. USA 2000; 97(7): 3702-3707.
2. Snyder, S.H., et al., Proc. Natl. Acad. Sci. USA 1981; 78(5): 3260-3264.

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