p21, GST-Tag Recombinant

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Catalog #

101584

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Description

Recombinant human p21 transcript 1, full-length encompassing amino acids 2-164 (end). This construct has an N-terminal GST-tag. This protein was affinity purified.

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Synonyms

Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6 (MDA-6), CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, p21

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4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Construct

p21 (GST-Pre-2-164(end))

Host Species/Expression System

E. coli

Purity

≥85%

Format

Aqueous buffer solution.

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

45 kDa

Amino Acids

2-164(end)

Genbank #

NM_000389

UniProt #

P38936

Tag(s)

N-Terminal GST-Tag

Background

P21, also known as cyclin dependent kinase inhibitor 1A or CDKN1A, inhibits cyclin/CDK (cyclin dependent kinase) complexes and thus inhibits DNA repair and cell cycle progression. P21 also interacts with PCNA (proliferating cell nuclear antigen) and has been reported to inhibit apoptosis. It is activated by p53 and negatively regulated by the E3 ubiquitin ligase complex SCF (Skp, cullin, F-box containing complex). Expression of cytosolic p21 has been linked to cancer, and can be used as a prognostic tool. Studies focusing on p21 will continue to advance the cancer therapy field.

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Datasheets/Protocols

101584 Lot 230629-C

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