c-Mer, GST-tag (Human) Recombinant
Catalog #
40254
$385
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Description
Recombinant human c-Mer, (also known as tyrosine-protein kinase Mer and MERTK) encompassing amino acids 578-872 and containing the kinase domain. This construct contains an N-terminal GST-tag. This recombinant protein was affinity purified.
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Synonyms
tyrosine-protein kinase Mer, MERTK, receptor tyrosine kinase MerTK
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Construct
c-Mer (GST-578-872)
Host Species/Expression System
Sf9 insect cells
Purity
≥90%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0,
110 mM NaCl, 2.2 mM KCl, 0.04%
Tween20, 20% glycerol, and 1.6 mM
glutathione
MW
60 kDa
Amino Acids
578–872
Specific Activity
≥50 pmol/min/µg
Genbank #
NM_006343
UniProt #
Q12866
Background
c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family (1). The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product (2).
References
1. Van Hoof, C. et al., Genomics. 1995; 28:
261-272.
2. Chao, Y. et al., Molec. Cell. 2006; 23: 535-546.
2. Chao, Y. et al., Molec. Cell. 2006; 23: 535-546.