MYLK2, His-tag Recombinant

Catalog #

40135

$410 *

Size: 10 µg

Qty

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Description

Recombinant human MYLK2, full length, with N-terminal His-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

skMLCK, KMLC, MLCK, MLCK2

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM sodium phosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol

74 kDa

Amino Acids

full length

Genbank #

NM_033118

UniProt #

Q9H1R3

Tag(s)

N-terminal His-tag

Background

MYLK2 is a member of the myosin light chain kinase family and is a calcium/calmodulin dependent enzyme that is exclusively expressed in adult skeletal muscle (1). MYLK2 has been proposed to participate in signaling pathways (calcium signaling pathway, focal adhesion, regulation of actin cytoskeleton) and cellular processes (neuromuscular synaptic transmission, protein/amino acid phosphorylation). MYLK2 is involved in multiple molecular functions as a result of various subdomains that participate in ATP binding, calmodulin binding, nucleotide binding, protein serine/threonine kinase activity and transferase activity) (2).

References

1. Soung, Y.H. et al:, Mutational analysis of the kinase domain of MYLK2 gene in common human cancers.Pathol Res Pract. 2006;202(3):137-40.
2. Toth-Zsamboki, E. et al. P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.J. Biol Chem. 2003; 21;278(47):46661-7.

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MYLK2, His-tag Recombinant

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