MARK1, GST-tag Recombinant

Catalog #

40119

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human MARK1, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

This product has been cited 1 time.

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Synonyms

MARK, KIAA1477

Product Info

Storage and Usage

Citations1

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

125 kDa

Amino Acids

full length

Genbank #

BC114478

UniProt #

Q9P0L2

Tag(s)

N-terminal GST-tag

Background

MARK1 is a member of the MARK family and is a serine/threonine-protein kinase that plays a key role in signal transduction. Due to its protein serine/threonine kinase activity, MARK1 is known to mediate phosphorylation of key proteins involved in signal transduction and cell communication. MARK1 phosphorylates microtubule-associated proteins and trigger microtubule disruption (1). Gene mutation studies performed in mice revealed that after targeted disruption of the MARK1 gene, the mice lacked the ability to drink, and displayed hind leg motor dysfunction (2).

References

1. Drewes, G. et al: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 1997; 89:297-308.
2. Manabu, N. et al: A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. The FASEB Journal. 2006; 20:1718-1720.

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MARK1, GST-tag Recombinant

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