KIR3DL3, Avi-His-Tag Recombinant
Recombinant KIR3DL3 (Killer Cell Immunoglobulin-like Receptor 3DL3) encompassing amino acids 26-322. This construct contains a C-terminal Avi-Tag™, followed by a His-Tag (6xHis). The recombinant protein was affinity purified.
≥90%
Aqueous buffer solution.
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
KIR3DL3, also known as Killer Cell Immunoglobulin-like Receptor 3DL3, is an inhibitory receptor present in NK cells. It is a framework gene, and present in all human haplotypes. In healthy individuals it is expressed at very low levels in CD8+ TEMRA and CD56dim NK cells, but in certain pathologies its levels are increased. It was recently found that B7-H7 is a ligand for KIR3DL3, an interaction that leads to NK cell suppression. Its role as immune checkpoint makes it an attractive target in cancer therapy.
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