HCK, GST-tag Recombinant

Catalog #

40440

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human HCK (230-497) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_002110.

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Synonyms

JTK9

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Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

57 kDa

Amino Acids

230–497

Specific Activity

171 pmol/min/µg

Genbank #

NM_002110

UniProt #

P08631

Tag(s)

N-terminal GST-tag

Background

HCK, a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells and especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes (1). HCK gene is located on chromosome sequence 20q11-q12, a region that is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders suggesting damage to HCK may contribute to the pathogenesis of these conditions (2).

References

1. Ziegler, S F. et al. Molec. Cell. Biol. 7: 2276- 2285, 1987.
2. Quintrell, N. et al. Molec. Cell. Biol. 7: 2267- 2275, 1987

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HCK, GST-tag Recombinant

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