FRK, GST-tag Recombinant

Catalog #

40424

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human FRK (208-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_002031.

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Synonyms

GTK, RAK, PTK5

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Product Data Gallery

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

60 kDa

Amino Acids

208–end

Specific Activity

997 pmol/min/µg

Genbank #

NM_002031

UniProt #

P42685

Tag(s)

N-terminal GST-tag

Background

FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in beta-cells from the pancreas increases the susceptibility of these cells to beta-cell-toxic events (hallmark of Type I diabetes)(2).

References

1. Craven, R J. et al. Cancer Res. 1995 Sep 15,55(18):3969-72.
2. Welsh, M. et al. Biochem J. 2004 Aug 15,382(Pt 1):261-8.

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FRK, GST-tag Recombinant

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