CLK1, GST-tag Recombinant

Catalog #

40196

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human CLK1 (a.a. 129-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

CLK, STY, CLK/STY

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

66 kDa

Amino Acids

129–end

Genbank #

NM_004071

UniProt #

P49759

Tag(s)

N-terminal GST-tag

Background

CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins (1), such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors (2).

References

1. Prasad J et al: Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol Cell Biol. 2003 Jun; 23(12): 4139-49.
2. Colwill, K. et al: SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J. Biol. Chem. 271: 24569-24575, 1996.

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CLK1, GST-tag Recombinant

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