Catalog #: 27611-1
Size: 5 mg
MW: 263.3 Da
CAS Registry #: 187389-53-3,634911-80-1
Formula: C11H18FNO5
Target: pan-caspase
Boc-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα) with IC50 value of 39 µM. Boc-D-FMK has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibits TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, Boc-D-FMK has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates.
A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. Can be used for both in vitro and in vivo studies--see note for using this product in vitro.
Caspase Inhibitor III; Boc-Asp(OMe)-FMK; Boc-D(OMe)-FMK; Boc-Asp-Fluoromethylketone; methyl 5-fluoro-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopentanoate

≥98% by HPLC

Soluble in DMSO
Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Cowburn AS,et al. Blood. 2005 Apr 1;105(7):2970-2.
2. Wu X, et al. Am J Physiol Renal Physiol. 2009 Aug;297(2):F316-26.
3. Sheen-Chen SM, et al. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1276-9.
The inhibitor is designed as a methyl ester to facilitate cell permeability. If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.
Amino Acid Sequence:
Scientific Category:
Apoptosis Inhibitor
Product Type:
Data shown is lot-specific. Contact us for specific information on other lots.

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