BLK, GST-tag Recombinant

Catalog #

40401

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant full-length human BLK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is BC007371.

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Synonyms

MGC10442

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Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥90%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

84 kDa

Amino Acids

full length

Specific Activity

112 pmol/min/µg

Genbank #

BC007371

UniProt #

P51451

Tag(s)

N-terminal GST-tag

Background

BLK, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. BLK is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells (1). Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of BLK (2).

References

1. Dymecki, SM. et al. Science. 1990 Jan 19;247(4940):332-6.
2. Burkhardt, AL. et al. Proc Natl Acad Sci USA. 1991 Aug 15;88(16):7410-4.

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BLK, GST-tag Recombinant

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