Bendamustine HCl
Catalog #
27738-1
$135
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Description
Bendamustine HCl is an alkylating agent associated with DNA damage (IC50 = 50 µM). It is a cytostatic agent that displays activity in non-Hodgkin's lymphomas.
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Synonyms
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
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Product Data Gallery
Product Info
Storage and Usage
Citations
Formula
C16H21Cl2N3O2 •HCl
MW
394.7 Da
Solubility
Soluble in DMSO
Biological Activity
Bendamustine exhibited anti-proliferation effects on dexamethasone-sensitive (MM1.S) and -resistant (MM1.R) multiple myeloma cells in a dose-dependent manner, with IC50s of 119.8 µM (MM1.S) and 138 µM (MM1.R), respectively. The apoptosis by activation of caspase-3 and caspase-8 was induced in both MM1.S and MM1.R cell lines.
CAS Registry #
3543-75-7
Background
Bendamustine inhibits mitotic checkpoints and induces mitotic catastrophe by inhibiting several mitosis-related genes such as Polo-like kinase 1, Aurora kinase A, and Cyclin B1. In myeloma cell lines, bendamustine induced apoptosis by cleavage of caspase 3, and resulted in G2 cell cycle arrest. In chronic lymphocytic and mantle cell lymphoma cell lines, bendamustine HCl has been shown to activate both the mitochondrial cell death pathway and caspase-dependent apoptosis.
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