ALK2, GST-tag

Catalog #: 40019
Size: 10 µg
$370
Species: Human
Host Species: Sf9 insect cells
MW: 67 kDa
Genbank #: NM_001105
Tag(s): N-terminal GST-tag
a.a: 147–end
Background:
ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFβRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells (1). Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues (2).
Description:
Recombinant human activin receptor-like kinase 2, or ALK2 (a.a. 147-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_001105.
Synonym(s):
ActRIA, ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI, ALK
Purity:
≥75%
Formulation:
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20 % Glycerol and 3 mM DTT.
Format:
Aqueous buffer solution
Storage / Stability:

>6 months at -80°C.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):
1. Craft, C.S. et al . Oncogene. 2007 Nov 8;26(51):7240-50.
2. Shore, E. M. et al . Nature Genet. 38: 525-527, 2006.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Kinase/Serine-Threonine
Product Type:
Recombinant Protein
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