PKC ι/λ, GST-tag Recombinant

Catalog #

40015

$355 *

Size: 10 µg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Human PKC iota (PCKι), also known as PKClambda (PKCλ), GenBank Accession No. NM_002740, a.a. 2-587 with N-terminal GST-tag, expressed in a Baculovirus infected Sf9 cell expression system. MW= 93 kDa.

●

Synonyms

Protein Kinase C Iota, PCKi, PKClambda, Protein Kinase C Lambda, PCKl, PKCι, PKCλ

●

Product Data Gallery

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Format

Aqueous buffer solution

Formulation

25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 3mM DTT and 50% glycerol.

93 kDa

Amino Acids

2–587

Genbank #

NM_002740

UniProt #

P41743

Tag(s)

N-terminal GST-tag

Background

PKCι (PKC iota) is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKCι showed greatest homology to PKCζ (PCKzeta), with 72% identity overall rising to 84% in the catalytic domain. Protein kinase Cι (PKCiota) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKCι in the colon are highly susceptible to carcinogen-induced colon carcinogenesis.

References

1. Zhang, J. et al., J. Biol. Chem. 279, 22118- 22123 (2004).
2. Gustrafson, W.C. et al., J. Biol. Chem. 279, 9400-9408 (2004).

Skip to the end of the images gallery

Skip to the beginning of the images gallery

PKC ι/λ, GST-tag Recombinant

PRODUCTS

SERVICES

RESOURCES

COMPANY