TXK, GST-tag Recombinant

Catalog #

40486

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human TXK (a.a. 239-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

RLK; TKL; BTKL; PTK4; PSCTK5; MGC22473

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

53 kDa

Amino Acids

239–end

Genbank #

NM_003328

UniProt #

P42681

Tag(s)

N-terminal GST-tag

Background

TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor. TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity (1). Excessive TXK protein expression is seen in patients with Behcet's disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet's disease (2).

References

1. Czar, M J. et al: Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk. Biochem Soc Trans. 2001Nov;29(Pt 6):863-7.
2. Suzuki, N. et al: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. Clin Med Res. 2006 Jun;4(2):147-51.

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TXK, GST-tag Recombinant

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