TCID

Catalog #

27720-1

$215 *

Size: 10 mg

Qty

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Description

A potent and selective inhibitor of ubiquitin C-terminal hydrolase L3 (UCH-L3) (IC50 = 0.6 µM). Inhibits ubiquitin C-terminal hydrolase L1 (UCH-L1) only at higher concentrations (IC50 = 75 µM).

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Synonyms

4,5,6,7–tetrachloro–1H–indene–1,3(2H)–dione

Product Info

Storage and Usage

Citations

Purity

≥97% by TLC.

Format

White powder

Formula

C9H2Cl4O2

283.9 Da

Solubility

Soluble in DMSO (25 mg/ml)

CAS Registry #

30675-13-9

References

1. Love, K.R. et al. Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat. Chem. Biol. 2007. 3:697.
2. Mtango, N.R. et al. Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation. J. Cell Physiol. 2012. 227:2022.

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